Monday, November 20, 2006

THERAPEUTIC CLONING


Imagine brain stem cell cloning from one embryo to alleviate or erradicatelon-standing pathologies which have ended a multitude of lives? What would it be like to end diabetes mellitus, leukemias, tissue dysplasias, glaucomas, immnosupressive disorders, arthitis and hypertension. For one medicine's focus would have to change.
What would it take to find enough production beta cells, abort tissue or fluid autoimmune destruction, abort optic nerve atrophy or even graft it? Or even allow for control of vasdilation and vasoconstriction of vessels thru the natural physiologic process without pharmacological aid?
The regulation of benefit for the wide variety of individuals would have to fall on a governmental agency, private agency or who would be in control of the multiple how's? How would the medical perspective influence handle patient selection? What about those transplant wating list patients with diseased organs? Reimbursement: private or public? If it would resemble anything like our present system what an oppurtnity for colossal confusion and frustation!
Mal-beneficience vs benefit to humankind. Faiths of all creeds vs the premise to benefit all. Conservatives alleging "play god " and obstruct science. Radicals advance science and aid humankind as whole. What about the middle of the these cross-roads? Are we not on top of the list as a industrialized nation? Are we not a culture with a meltdown from several other roots? And we profess the pursue of liberty and happiness to all. And if we have created human form in the laboratory already? What about pursuing technology for therapeutic cloing exclusively?
An opthalmic perspective on therapeutic cloning goes without elaborating on the idea about grafting or regenerating optic nerve fibers for open angle glaucoma. What about regenerating macular degeneration or annihilating diabertic macular edema? As sad as it is truth our patients are losing sight despite our best intentioned efforts to prevent these pathologies. Yes, of course we have pharmaceutical agnets to increase/reduce introcular flow, laser beams to interfere with the trabecular meshwork and its outpour of intraocular flow. And last but, not least we have valves transplanted to scleras to obtain a definite device to control introcular pressure. However, we are still encountering endstage glaucoma and BLINDNESS. What about our present early prophylaxis for macular degeneration: sunglasses, vitamins and wide brim head coverage. Someone tell me that therapeutic cloning for the retina would not alleviate this pathology? Our worst case scenario surgery or intravitreal injections to absorb and reduce inflammation. And diabetic retionpathy: laser vs intravitreal cortisone or other anti-inflammatory agents.
Advances, most definitely, however full resolution a dream!

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